Kamal Sowah, Baba Iddrisu and Kasim Adams will not be able to honor Ghana’s Cup of Nations qualifiers against South Africa and São Tomé.
The trio according sources have been prevented by their respective clubs who are unwilling to release the players.
All three players appeared in CK Akonnor’s 29-man squad for the two matches.
European Clubs have been reluctant on releasing their players for the upcoming international matches due to COVID-19 fears.
Portugal-based Gideon Mensah was earlier on ruled out of the games.
Goalkeeper Richard Ofori will also not be available for Ghana due to injury.
The team is expected to leave for South Africa today.